摘要
目的观察胃癌中C-erbB-2的表达情况及其与患者年龄、性别、分化程度、淋巴结转移及预后的关系,探讨C-erbB-2在胃癌中表达的临床病理学意义。方法采用免疫组化SP法测定75例胃癌组织中C-erbB-2的表达。结果淋巴结转移组的C-erbB-2阳性率高于非转移组(P<0.05);C-erbB-2阴性组患者的预后优于C-erbB-2阳性组(P<0.01);胃癌组织中C-erbB-2表达与肿瘤分化程度及患者的性别、年龄无关。结论胃癌组织中C-erbB-2表达与肿瘤淋巴结转移有关,并可作为胃癌预后的判断指标。
Objective To explore the expression of C-erbB-2 protein in gastric carcinoma and its relationship with clinicopathological features and prognosis. Methods The expression of C-erbB-2 protein in 75 cases of gastric carcinoma was assessed by immunohistochemistry. Results The positive rate of C-erbB-2 in cases of lymph node metastases was significantly higher than those without lymph node metastases（P 〈 0.05）. The survival rate in C-erbB-2-positive cases was significantly lower than in C-erbB-2-negative cases （P 〈 0.01）. The expression of C-erbB-2 had no correlation with age, sex and differentiation. Conclusion The expression of C-erbB-2 could be used to predict prognosis in patients with gastric carcinoma.
出处
《山西医科大学学报》
CAS
2007年第11期1021-1023,共3页
Journal of Shanxi Medical University
