摘要
目的探讨结肠癌中ILK与p53的表达情况及其与相关临床病理参数之间的关系。方法采用免疫组织化学方法检测93例结肠癌中ILK与p53的表达情况,对染色结果进行分析与临床病理参数之间的关系。结果在93例结肠腺癌中ILK的阳性表达率为57%(53/93),在93例结肠腺癌中p53的阳性表达率为43%(40/93),p53的表达在性别、年龄、淋巴结转移、肿瘤复发、肿瘤分期、分化程度方面差异无统计学意义(P>0.05)。结论 ILK和p53的表达体现了结肠癌的生物学特性,ILK与p53可以作为结肠癌预后的一个生物学标记。
Objective To detect the expression of ILK and p53 proteins in colorectal carcinomas and to determine their association with clinicpathological characteristics. Methods Immunohistochemistry method was used to detect the expression of ILK and p53 proteins in 93 cases of colorectal carcinoma. The stain results were obtained by analyzing the clinicpathological characteristics of patients, Results Fifty-seven percent （53/93） of the colorectal carcinomas were ILK protein positive. The positive rate of p53 protein was 43% （40/93） in colon carcinomas. No significant correlation was observed in p53 protein expression in patients with different gender, age, lymphatic metastasis, tumor recurrence, tumor staging, differentiation degree （P 〉 0.05）. Conclusion The expression of ILK and p53 represent biological characteristics of colorectal carcinomas. Assessment of both ILK and p53 status may be valuable in predicting the prognosis of patients.
出处
《中国当代医药》
2013年第7期9-10,13,共3页
China Modern Medicine
关键词
结肠癌
ILK
P53
预后
Colorectal carcinoma
ILK
p53
Prognosis
