摘要
目的:观察乳腺癌组织中微血管密度(MVD)的分布,探讨其与临床病理特征及复发之间的关系,评价MVD对预后判断的价值。方法:采用免疫组化SABC法,检测74例乳腺癌组织内微血管生成情况,并随访预后情况。结果:肿瘤越大,肿瘤分级越高,其MVD越高(P<0.05)。有腋淋巴结转移的MVD明显高于无淋巴结转移者(P<0.05)。复发患者的MVD明显高于无复发者(P<0.01)。VEGF C-erbB-2阳性组的MVD明显高于阴性组(P<0.05)。未发现MVD与P53、ER有相关性(P>0.05)。结论:肿瘤组织内微血管的生成程度与乳腺癌的复发转移密切相关,微血管密度可作为评估乳腺癌患者预后的指标之一。
Objective：To investigate the microvessel density（MVD） in breast carcinoma,and the relationship between MVD and clinical pathology relapse,and prognosis.Methods：To determine the level of microvessel density in 74 patients with breast cancer,by strepto avidin biotionperoxidase complex（SABC）.The patients were followed up.Results：The expression of MVD signifiantly increased with tumor size and histologic grade （P〈0.05）.MVD of patients with lymphatic metastasis was higher than that of patients without lymphatic metastasis（P〈0.01）.The MVD in recurrent patients was higher than that in patients without recurrence（P〈0.01）.The MVD was significantly different between VEGF,cerbB2 positive and negative group（P〈0.01）.No relationship were found between MVD P53 expression and ER.Conclustion：There are close relationship between NVD and relapse metastasis of breast cacer.Examing MVD may be helpful in predicting prognasis of breast cancer.
出处
《现代肿瘤医学》
CAS
2010年第9期1751-1753,共3页
Journal of Modern Oncology
关键词
乳腺癌
微血管密度
免疫组织化学
预后
breast cancer
microvessel density
immnuohistochemical
prognosis
