摘要
随着人们生活条件的改善,对食物卫生的要求亦越来越高,随之而来的食物过敏的发生率也越来越高,日趋严重地危害着人们的身体健康。食物过敏主要是由于机体摄入的食物中所含的外源性蛋白质进入肠道黏膜免疫系统后,导致机体免疫应答向Th2型免疫应答发展,使Th1/Th2免疫动态平衡失调,过度分泌细胞因子(IL-4、IL-5和IL-13),产生特异性抗体IgE,导致肥大细胞脱粒,组胺释放,肠道微生物区系变化等症状。目前,在预防和治疗食物过敏性疾病方面已有很多报道,唯独益生菌疗法备受青睐。因为益生菌作为肠道中的土著菌群不仅可预防和治疗食物过敏,而且还能通过分泌γ干扰素(IFN-γ)、IL-10和转化生长因子β(TGF-β)等细胞因子,以调控机体的免疫应答,恢复免疫系统的动态平衡。
With the improvement of living conditions,people pay more attention to food sanitation,following which the incidence rate of food allergy is higher and higher.Food allergy threatens public health seriously.It is caused mainly by dominance of T helper type 2-based immune responses,which breaks the dynamic balance of Th1/Th2 immune responses and resultes in over secreting of IL-4,IL-5 and IL-13,production of specific antibody IgE,degranulation of mast cells,alteration of intestinal microflora and so on.At present,a lot of investigations have been reported,of which the probiotics therapy attracted more attention.As the indigenous flora,probiotics could not only prevent and treat food allergy but could also modulate immune responses and recover the dynamic balance of it via secreation of cytokines such as IFN-γ,IL-10,TGF-β.
出处
《肠外与肠内营养》
CAS
2007年第5期305-308,312,共5页
Parenteral & Enteral Nutrition
基金
国家杰出青年科学基金资助项目(30025034)
国家重大基础计划项目(2004CB117500-4)
关键词
食物过敏
益生菌
免疫调控
应用
Food allergy
Probiotics
Immune modulation
Application
