摘要
目的分析食物过敏相关性儿童迁延性、慢性腹泻病的病因、临床特点、治疗以及疗效。方法对2006年9月至2010年3月在中国医科大学附属盛京医院小儿消化内科病房住院,病因未明的诊断为迁延性、慢性腹泻病60例患儿的临床资料进行回顾性分析,其中过敏组53例,非过敏组7例。分析过敏原的分布、相关化验结果的变化情况以及食物过敏相关性迁延性、慢性腹泻的临床特点。结果 88.33%的患儿存在1~10种不等的食物过敏。IgG抗体检测结果阳性率:牛奶>蛋清蛋黄>西红柿>鳕鱼=大豆>蟹=大米>牛肉=虾=小麦>鸡肉=玉米>蘑菇=猪肉。过敏组IgM高于非过敏组(P=0.01),2组中性粒细胞、嗜酸细胞、便常规、肠道菌群、总蛋白、白蛋白、免疫球蛋白差异无统计学意义(P>0.05)。经回避过敏原、黏膜保护剂、微生态制剂治疗后患者的腹泻症状多有不同程度的缓解,治疗总有效率差异有统计学意义(P=0.01)。结论未知病因的迁延性、慢性腹泻患儿多数存在食物过敏,该类患儿临床表现及常规化验检查与非过敏患儿表现类似。回避过敏原的诊断性治疗后腹泻好转。过敏原检测对儿童未知病因的迁延性、慢性腹泻的诊治具有一定意义。
Objective To analyze the cause,clinical characteristics and treatment effect of children with chronic diarrhea associate with food allergy.Methods The related clinical informations of children with chronic diarrhea who were treated in department of pediatrics of shengjing hospital from September 2006 to March 2010 were recorded and analysed in detail.To analyze the distribution of allergen,the variation of related clinical informations.Results 88.33% chronic diarrhea children had food allergy especially for 1 to 10 foods.The positive rate of IgG test:milk>egg>tomato>cod=soy>crab=rice>beef=shrimp=wheat>chicken=maize>mushroom=pork.IgM of allergy group was higher than non-allergy group(P=0.01).There were no significant differences between the two groups in neutrophils,acidophilus,stool,intestinal bacteria,total protein,albumin and immunoglobulin(P>0.05).Curative efficacy of avoid allergen,mucosa protector,microecological bacteria of allergy group was favorable and different from non-allergy group(P=0.01).Conclusions Most of chronic diarrhea in children whose pathogenesis is still unknown exist food allergy.The patients' clinical character and normal laboratory tests are similar.Diarrhea are relieved after diagnostic treatment of avoid allergic food.The test of allergen is meaningful for chronic diarrhea in children whose pathogenesis is still unknown.
出处
《中华临床医师杂志（电子版）》
CAS
2011年第14期4043-4047,共5页
Chinese Journal of Clinicians(Electronic Edition)
关键词
食物过敏
慢性腹泻
儿童
口服耐受
Food hypersensitivity
Chronic diarrhea
Child
Oral tolerance
