摘要
目的:探讨急性白血病(AL)化疗后医院感染(HAI)的易感因素、防治方法及预防措施。方法:对93例初治AL患者住院化疗后的医院感染发生及治疗情况进行回顾性分析。结果:中性粒细胞计数(ANC)降低、年龄>60岁、未能完全缓解(CR)患者医院感染率增高,抗生素联合粒细胞集落刺激因子(G-CSF)治疗使化疗后AL患者发热及ANC恢复天数分别缩短为(7.0±1.89)d和(6.0±1.3)d。结论:AL患者化疗后ANC降低、患者年龄>60岁及未获得CR是医院感染主要易感因素,抗生素加用G-CSF合理应用,能减少医院感染发生率及严重程度。
Objective：To investigate the risk factors of nosocomial infection after chemotherapy in acute leukemia patients, and discuss the methods of prevention and treatmeat. Method：Ninety-three nosocomial infection cases and their therapy were analyzed retrospectively in acute leukemia patients who had chemotherapy. Result： The infection rate of the patients whose age exceeded 60, had lower absolute neutrophil count （ANC） and didnot reach complete remission were higher. Combining antibiotic therapy and GSF shortened the days of fever and recover of ANC to 7.00±1.8, 9.8±2.0, days respectively. Conclusion：The lowl ANC and old ages of the patients are the primary risk factors that lead to nosocomial infection; Combining antibiotic therapy and GSF could reduced the nosocomial infection rate and its seriousness.
出处
《临床血液学杂志》
CAS
2007年第6期339-340,343,共3页
Journal of Clinical Hematology
关键词
白血病
急性
医院感染
治疗
Acute leukemia
Nosocomial infection
Therapy
