摘要
目的观察食物过敏后,机体的体液免疫情况,探讨食物过敏在肠易激综合征(IBS)发病中的作用和作用机制。方法对腹泻型 IBS 患者55例、便秘型 IBS 患者32例和健康对照组18例,采集外周静脉血,应用酶联免疫方法,进行14种食物抗原的特异性抗体 IgE 和 IgG 检测。结果腹泻型 IBS 血清食物特异性 IgE 抗体的阳性率43。64%,高于正常对照组,而便秘型 IBS 仅为15.63%,与正常对照差异无统计学意义。腹泻型 IBS 和便秘型 IBS 的 IgE 抗体阳性率存在差异。在食物特异性IgE 抗体阳性的 IBS 患者中,多种食物阳性者48.28%。腹泻型 IBS 食物特异性 IgG 抗体的阳性率63.64%,便秘型 IBS 的阳性率为43.75%,两者均高于对照组,并且两组间比较差异无统计学意义。在食物特异性 IgG 抗体阳性的 IBS 中,多种食物阳性者51.02%。结论食物过敏介导的体液免疫反应异常在肠易激综合征的发病机制中,具有重要的作用。腹泻型肠易激综合征同时存在 IgE 和 IgG介导的免疫异常反应,便秘型肠易激综合征只存在 IgG 介导的免疫异常反应。
Objective To observe the abnormal humoral immune reactions after allergy and expound the etiopathological role and mechanism of food allergy in IBS. Methods The food-specific IgE and IgG antibodies to a panel of 14 different food antigens in serum were detected by an enzyme linked immunosorbant assay （ELISA） in fifty five cases with diarrhea-dominant IBS, thirty two with constipation-dominant IBS and eighteen normal controls. Results The positive rate of serum food-specific IgE antibodies in patients with diarrhea-dominant IBS was 43.64 percent, which was higher than that in normal controls. While 15.63 percent was positive in constipation-dominant, which had no difference compared with that in normal controls. There was different between the patients with diarrhea-dominant IBS and constipation-dominant IBS in the positive rate of serum food-specific IgE antibodies. Among the patients with positive serum The positive rate of serum food-specific IgG antibodies was 63.64 percent in patients with diarrhea-dominant IBS, and 43.75 percent in constipation-dominant IBS. Both of them were higher than that in normal controls. But there was no difference between them. Among the patients with positive serum food-specific IgG antibodies, 51.02 percent was allergic to many kinds of foods. Conclusion The abnormal humoral immune reactions mediated by food allergy played an important role in the development of IBS. Abnormal immune reactions mediated by IgE and IgG antibodies coexisted in patients with diarrhea-dominant IBS. Only that mediated by IgG antibodies exis- ted in patients with constipation -dominant cases.
出处
《中华消化内镜杂志》
2007年第5期346-349,共4页
Chinese Journal of Digestive Endoscopy
