摘要
目的原发性渗出性淋巴瘤是国内外少见肿瘤之一,探讨其临床表现及病理学特征,以便提高对该病的认识。方法报道1例原发性渗出性淋巴瘤,观察其临床表现,并对腹水进行细胞学、免疫组化及原位杂交检查并文献复习。结果患者男性,54岁。临床表现为腹腔腹水,无明确肿物,全身表浅淋巴结无肿大,血HIV(-)。肿瘤细胞形态类似浆母细胞样和浆细胞样的异型淋巴细胞。免疫组化:LCA、CD38和bcl-2(+),CD30弱(+),CD20、CD3、CD79a、CD138、κ、λ和EBV(-),Ki-67阳性率65%。原位杂交EBER(-)。结论原发性渗出性淋巴瘤的诊断依靠临床表现、细胞形态和免疫表型;需要与脓胸相关性淋巴瘤和B细胞性免疫母细胞淋巴瘤等肿瘤鉴别;少数病例可能与HIV和EBV感染无关。
Objective To investigate the clinicopathological characteristics of the primary effusion lymphoma and improve the realization of the tumor. Methods Chnical manifestations of one primary effusion lymphoma were analyzed with review of the relevant hterature. Coeliac effusion of the patient was studied by means of histopathological observation, immunohistochemical staining and in situ hybridization. Results The case was a fifty-four years old man, presented with coeliae serous effusion without detectable tumour masses and lymphadenopathy. HIV was not detected in blood. Turnout cells resembled plasmablast and plasmaeyte. The tumor was positive for LCA, CD38 and bcl-2 weakly positive for CD30, and negative for CD20, CD3, CD79a, CD138, κ,λ and EBV、 Ki-67 positive index was 65%. EBER was negative. Conclusion The diagnosis of primary effusion lymphoma relies on the combination of elinieul features, cell morphology and immunophenotypes, which should to be distinguished from pyothorax associated DLBCL and B immunoblastie lymphoma. A few eases reported are not associated with HIV and EBV.
出处
《诊断病理学杂志》
CSCD
2007年第5期344-346,共3页
Chinese Journal of Diagnostic Pathology
关键词
原发性渗出性淋巴瘤
免疫组化
诊断
鉴别诊断
Primary effusion lymphoma
Immunohistochemistry
Diagnosis
Differential diagnosis
