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双功能基因APE1/Ref-1:肿瘤治疗的新靶点 被引量:4

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摘要 脱嘌呤脱嘧啶核酸内切酶/氧化还原因子(apurinic/aprimidinic endonuclease/redox factor-1,APE1/Ref-1)是一个生物大分子功能复合体的范例,它不仅是DNA碱基切除修复(base excision repair,BER)途径的主要限速酶,而且是一种重要的氧化还原因子,通过调控多种转录因子氧化还原状态而改变其转录活性。APE1/Ref-1参与多种重要的细胞生物学过程,是DNA损伤修复、氧化应激和转录因子调控基因表达的重要枢纽分子,对细胞凋亡、增殖和分化有重要的影响。
作者 王东
出处 《重庆医学》 CAS CSCD 2007年第19期1911-1912,1914,共3页 Chongqing medicine
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