摘要
目的：探讨阿霉素（Ａｄｒ）脂质体对小鼠肝癌２２细胞（Ｈ２２）和肉瘤１８０细胞（Ｓ１８０）肿瘤的抗肿瘤活性。方法：将Ａｄｒ包封于二棕榈酸磷脂酰胆碱（ＤＰＰＣ）和大豆甾醇（ＳＳ）以及含有聚乙二醇（ＰＥＧ）的两种脂质体（ＤＰＰＣ／ＳＳ和ＤＰＰＣ／ＳＳ／ＰＥＧ脂质体）中，连同游离Ａｄｒ，共３种样品，分别对接种了Ｈ２２和Ｓ１８０的小鼠进行了尾静脉注射治疗实验。结果：Ａｄｒ脂质体对Ｈ２２腹水型肝癌和Ｓ１８０肉瘤的动物生命延长率和抑制效果优于游离的Ａｄｒ，而且ＤＰＰＣ／ＳＳ／ＰＥＧ脂质体的抗癌效果更好。结论：将脂质体作为抗癌药物Ａｄｒ的载体，对小鼠Ｈ２２腹水癌和Ｓ１８０肉瘤的治疗有效。
OBJECTIVE: To investigate the antitumor activity of adriamycin liposomes (Adr liposomes) against H 22 and S 180 tumors in mice. METHODS: Adriamycin (Adr) was encapsulated in dipalmitoylphosphatidylcholine (DPPC) and soybean derived sterol (SS) as well as PEG DSPE liposomes (DPPC/SS liposomes and DPPC/SS/PEG liposomes). The two kinds of liposomes and free Adr were administered in the tail vein in H 22 and S 180 tumor bearing mice. RESULTS: The antitumor efficacy of Adr encapsulated in DPPC/SS liposomes and DPPC/SS/PEG liposomes was active than that of the free drug and the DPPC/SS/PEG liposomes were markedly active. CONCLUSION: These results indicate that liposomes delivery Adr may provide antitumor activity of Adr against H 22 and S 180 cancer.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1997年第4期207-210,共4页
Chinese Pharmaceutical Journal
关键词
阿霉素脂质体
抗肿瘤活性
聚乙二醇
药理
Adr liposomes, antitumor efficacy, polyethylene glycol (PEG), H 22 , S 180
