摘要
目的:探讨儿童肥胖的临床特点,分析儿童肥胖与代谢综合征(MS)各指标之间的关系。方法:从我市区健康体检3087名儿童中,选择肥胖儿童(肥胖组)42例和正常体重儿童(对照组)34例,调查家族史、生活方式,测定肥胖指数(BMI),收缩压(SBP)、舒张压(DBP),血脂谱(甘油三酯TG、总胆固醇TC、高密度脂蛋白HDL-C、低密度脂蛋白LDL-C),空腹胰岛素(FIS),空腹血糖(FPG),计算胰岛素敏感指数(ISI)和抵抗指数(IR),超声肝脏。结果:(1)肥胖儿童一级亲属(父母亲)有肥胖和高血压阳性家族史分别是19.47%和11.94%,有92.86%肥胖儿童饮食过剩或偏食,有83.33%肥胖儿童运动量较少。(2)肥胖组TG、SBP、DBP高于正常对照组,TC、HDL-C和LDL-C组间差异无统计意义。(3)肥胖组空腹胰岛素含量为正常组的2倍,并与BMI显著正相关(r=0.55)。(4)超声图显示:肥胖组8例脂肪肝,3例反光点增多,明显高于正常组。结论:(1)肥胖存在家族遗传倾向,但多食少动生活方式对肥胖的发生贡献更大。(2)肥胖儿童血脂谱异常、易发脂肪肝。(3)肥胖儿童高胰岛素血症和胰岛素抵抗普遍存在。(4)肥胖与代谢综合征有某种联系,在多种心血管危险因素集聚中,肥胖效应强于其它因素。(5)儿童肥胖重在预防,建议合理饮食、加强锻炼,从上游阻断代谢综合征引发的各种不良事件的发生。
Objective：To investigate the clinical features of children obesity, and analyze the the correlation between children obesity and indexes of metabolism syndrome. Methods： 42 children with obesity（obesity group） and 34 normal children（control group）were investigated with respect to their family history and lifestyle, their body mass index （BMI）, systolic pressure, diastolic pressure, triglyceride （TG）, cholesterol （TC）, high density lipoprotein-cholesterol （HDL-C） ,low density lipoprotein-cholesterol（LDL-C） ,fasting insulin,fasting glucose were messured, insulin sensitive index（ISI） and insulin resistence（IR） were calculated, and liver B-ultrasound were examined. Results： ① Positive family history of hypertension and obesity was 19. 47% and 11. 94% in first-degree relatives of children with obesity. 92. 86% children with obesity had a habit of eating much more and food preference,and 83. 32% children with obesity were less exercise. ② In obesity group TG,SBP,DBP were high than that in normal group, there was no significant, difference in TC, HDL-C,LHL-C among the two groups.③ In obesity group the fasting insulin was 2 times than that in the normal group,and was significantly positively correlated with BMI（r=0. 55）. ④ Ultrasound： there were 8 subjects with fatty liver and 3 subjects with reflectivity increase in the obesity group, there was significantly difference between the groups. Oonclusion： ① Obesity is probably dependent on the heredity, however, lifestyle of overeating and less exercise is able to play most important role.② Children with obesity has abnormal blood lipid, which produce fatty liver easly. ③Hyperinsulinemia and insulin resistance are the common phenomena. ④ Obesity is correlated to some extent with metabolism syndrome, obesity is the most important in all aggregation of cardiovascular risk factors. ⑤ The emphasis should be laid on the prevention of obesity. It is suggested that the children should have a sensible and restrictiv
出处
《医学理论与实践》
2007年第10期1138-1140,共3页
The Journal of Medical Theory and Practice
关键词
儿童肥胖
代谢综合征
胰岛素抵抗
Children obesity, Metabolism syndrome, Iinsuline resistance
