摘要
目的探讨胰岛素抵抗与中年冠心病患者冠状动脉狭窄的关系。方法118例疑诊冠心病的中年患者按冠状动脉造影的结果分成对照组(40例)及冠心病组(78例),冠心病组根据冠状动脉病变支数又分3个亚组:1支病变组,25例;2支病变组34例;3支以上病变组19例。冠脉造影前测定空腹胰岛素(FINS)和空腹血糖(FBG)、血脂等生化指标,并计算出胰岛素敏感指数ISI=LN[1/(FBG×FINS)]。结果①冠心病组与对照组比较,存在高胰岛素血症(P<0.05)和胰岛素敏感性降低(P<0.05);②随冠动脉病变支数的增加,FINS和ISI明显增高,2支病变组、3支以上病变组FINS和ISI显著高于1支病变组(P<0.05)。结论胰岛素抵抗与中年冠心病发生率成正比;与冠状动脉病变程度密切相关。
Objective To investigate the correlations between insulin resistance and middle-aged coronary heart disease（CHD）. Methods The coronary angiongraphy assessment of 118 patients with chest pain resulted in the control group（40） and the CHD group（78）. The CHD group was then subdivided into three groups based on the quantity of coronary lesion：the one lesion group（25）,the two-lesion group（34） and the three-lesion group（19）. The insulin sensitivity index ISI=LN[1/（FBG×FINS）] had been calculated on the basis of determining the fasting insulin （FINS）,fasting blood-glucose（FBG）and blood fat before the coronary angiography was undertaken. Results （1）The CHD group indicated a high index of insulinemia （P〈0.05）and a low index of insulin sensitivity（P〈0.05）,compared with the control group. （2）The high indices of FINS and ISI were highly correlated with the increase of the quantity of coronary lesion. The Indices of FINS and ISI is the two -lesion group and the three -lesion group were significantly higher than those in the one lesion group（P〈0.05）. Conclusion Insulin resistance is proportional to the incidence of midlle-aged CHD and strongly associated with the severity of midlle-aged CHD.
出处
《中国心血管病研究》
CAS
2007年第10期745-747,共3页
Chinese Journal of Cardiovascular Research
