摘要
[目的]探讨胰岛素抵抗与冠状动脉病变的关系。[方法]236例胸痛患者按冠状动脉造影的结果分成对照组(80例)及冠心病组(156例),冠心病组根据冠状动脉病变支数又分3个亚组:1支病变组,49例;2支病变组,69例;3支病变组,38例。冠脉造影前测定空腹胰岛素(FINS)和空腹血糖(FBG)、血脂等生化指标,并计算出胰岛素敏感指数ISI=LN[1/(FBG×FINS)]。[结果]①冠心病组患者与对照组比较,存在高胰岛素血症(P<0.01)和胰岛素敏感性降低(P<0.01);②随冠状动脉病变支数的增加,FINS和ISI明显增高,二支病变组、三支病变组FINS和ISI显著高于一支病变组(P<0.05)。[结论]胰岛素抵抗与冠心病发生率成正比;胰岛素抵抗与冠状动脉病变的广泛程度有密切的关系。
[Objective]To investigate the co,relations between insulin resistance and coronary heart disease （CHD）. [Methods] The coronary angiography assessmnent of 236 patients with chest pain resulted in the control group （80） and the CHD group （156）. The CHD group was then subdivided into three groups based on the quantity of coronary lesion： the one-lesion group （49）, the twolesion group （69） and the three-lesion group （38）. The Insulin sensitivity index { ISI = LN [ 1/（ FBG x FINS） ] } had been calculated on the basis of determining the fasting insulin （FINS）, fasting blood-glucose （FBG） and blood fat before the coronary angiography was undertaken. [Results]① The CHD group indicated a high index of insulinemia （P〈0.01） and a low index of insulin sensitivity （P〈0.01）, compared with the control group;② The high indices of FINS and ISI were highly correlated with the increase of the quantity of coronary lesion. The Indices of FINS and ISI in the two-lesion group and the three-lesion group were significantly higher than those in the one-lesion group （P 〈 0.05）. [Conclusion] Insulin resistance is proportional to the incidence of CHD and strongly associated with the severity of CHD.
出处
《广西中医学院学报》
2006年第3期1-3,共3页
Journal of Guangxi Traditional Chinese Medical University
关键词
冠心病
胰岛素抵抗
冠状动脉病变
：Coronary heart disease
Insulin resistance
Coronary lesion
