摘要
目的研究骨生康胶囊对骨折的治疗作用,并对其治疗的机理作初步探讨。方法在家兔桡骨中上段1/3交界处造成其骨折,术后次日灌胃给予骨生康胶囊,分别于给药后14,28d,测定骨折处骨矿物密度,并作组织病理学检查,同时测定血小板、血浆黏度。结果给药14d后,骨生康胶囊高、低剂量组的骨密度增加,与模型组比较有显著性差异(P<0.01,P<0.05);给药28d后,骨生康胶囊高、中剂量组的骨密度增加,与模型组比较有显著性差异(P<0.05);28d的骨密度比14d增加。病理组织学检查显示,损伤后骨组织于14,28d给药组的组织学形态都有所增生修复。给药14,28d后可降低血小板聚集率,28d时还可以降低血液黏度。结论骨生康胶囊可以加快骨矿沉积速率,提高骨密度,改善血液流变学,促进家兔骨损伤的修复。
Objective To investigate the therapeutic effect of Gushengkang Capsule （GC） on the catagmatic rabbits. Methods Rabbits models with fracture middle - superior segment of the radius were established and then were given GC. The bone mineral density （BMD） and biochemical indicators including serum alkaline phosphatase and Ca^2＋ 14 and 28 days after treatment were examined. At same time the parameters of histology and hemorheology in the fractured radius were also observed. Results The bone mineral density of high - and low - dosage GC group increased significantly after 14 - day treatment in the catagmatic rabbits （ P 〈 0.01 or P 〈 0. 05 as compared with the model group） ; after 28 - day treatment, BMD increased in high- and middle-dosage GC groups （P 〈 0. 05）. The changes of histology and hemorheology in GC groups were improved after 14 - and 28 - day treatment. Platelet aggregation rate was decreased in GC groups after 14 - and 28 - day treatment, and blood viscosity decreased after 28 - day treatment. Conclusion GC can improve and accelerate fracture healing in the catagmatic rabbits by increasing BMD and improving blood rheology.
出处
《中药新药与临床药理》
CAS
CSCD
2007年第5期372-374,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
骨生康胶囊
骨折模型
骨矿物密度
Gushengkang capsule
Fracture model
Bone mineral density
