摘要
目的 :评价补肾活血液延缓雄性大鼠骨衰老的作用。方法 :4 0只SD雄性大鼠随机分为 4组 ,每组 10只。分别作为 2 4月龄本底对照组、2 7月龄增龄对照组、补肾活血液低剂量组和补肾活血液高剂量组 ,增龄对照组不做任何处理 ,低剂量组、高剂量组均自 2 4月龄给药至 2 7月龄。进行相应处理后分别测定各组大鼠全身骨矿物密度(GBMD)、右侧股骨抗弯强度 (FBS)和血清骨钙素 (BGP)、尿羟脯氨酸 (U -Hyp)与肌苷 (U -Cr)。结果 :补肾活血液高剂量组的GBMD及FBS均高于 2 7月龄增龄对照组和补肾活血液低剂量组 ,但低于 2 4月龄本底对照组 ;高剂量组的BGP明显高于增龄对照组 (P <0 0 5 ) ,U -Hyp/Cr明显低于增龄对照组 (P <0 0 5 ) ,都与本底对照组相接近 ;低剂量组的BGP低于本底对照组 (P <0 0 5 ) ,U -Hyp/Cr明显高于本底对照组 (P <0 0 5 ) ,都与增龄对照组相接近。结论 :补肾活血液具有剂量依赖性地降低全身BMD的增龄性减少率和股骨抗弯强度的增龄性降低率 ,而延缓雄性大鼠增龄性骨质疏松的作用。
AIM: To evaluate efficiency of Chinese recipe of replenishing kidney and activating blood circulation(CRRKABC) to stave senile osteoporosis(OP) of male rats. METHODS: Forty male SD rats at age of 12 months were randomly divided into 4 groups: ①24 months background control; ②27 months aging control; ③CRRKABC (low dose) and ④CRRKABC (high dose). General bone mineral density (GBMD), femur bending strength (FBS), serum-BGP and urine-Hyp/Cr were measured. RESULTS: GBMD and FBS in CRRKABC (H) group were significantly higher than those in 27 months aging control group, but lower than 24 months background control group( P< 0.05); GBMD, FBS in CRRKABC groups were slightly higher than those in nylestriol's group ( P> 0.05). Furthermore, the level of serum-BGP in CRRKABC(H) group was higher and level of U-Hyp/Cr was lower than 27 months aging control group ( P< 0.05) but very close to that of 24 months background control group. The level of serum-BGP in CRRKABC (L) group was lower and level of U-Hyp/Cr was higher than 24 months background control group ( P< 0.05) but very close to that of 27 months background control group. CONCLUSION: CRRKABC could control osteoporosis in male rats induced by aging, in a dosedependant manner.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2001年第12期1205-1207,共3页
Chinese Journal of Pathophysiology
基金
广东省自然科学基金 (No .990 4 75 )
中国博士后科学基金 ( 1999年第 2期 )
广东省中医药管理局科学研究基金 (No.995 80
990 4 75 )资助项目
