摘要
目的:从肌动蛋白结构和功能的角度探讨运动对肌动蛋白及肌动蛋白基因表达的影响,并探索运动等因素影响肌动蛋白表达的有效途径,为科学训练提供依据。资料来源:应用计算机检索PubMed数据库1999-06/2006-06相关运动与肌动蛋白方面的文献,检索词"actin,α-actin,α-actinmRNA,aerobic exercise",限定文献语言种类为English。资料选择:对资料进行初审,选取包括运动与肌动蛋白的文献,开始查找全文。纳入标准:①有关肌动蛋白结构与功能的研究。②运动与肌动蛋白表达的实验研究。排除标准:重复或类似的同一研究、个案报道、偏重于临床医学的研究。资料提炼:共检索到126篇关于运动与肌动蛋白的文献,最终纳入31篇符合标准的文献。资料综合:肌动蛋白是真核细胞内最保守、含量最丰富的蛋白质之一,作为细胞骨架和结构的主要成分,具有极其重要的细胞生理功能;其在体内一般以球形肌动蛋白和纤维性肌动蛋白(即微丝)两种形式存在,是构成骨骼肌肌原纤维细丝的主要蛋白质,参与肌肉所有的收缩活动,从而完成机体的多种机械运动。蛋白质是基因的表达产物,基因表达中任何一个环节的改变都可以引起蛋白质含量的改变,虽然理论上基因表达的调控可以在表达过程的任何阶段进行,但实际上主要发生在转录的初始阶段。结论:不同运动方式对骨骼肌蛋白质及其基因表达的影响不同。
OBJECTIVE： To discuss the effect of exercise on the expression of actin protein and mRNA from actin structure and function, and explore the effective approaches of exercise and other factors on actin expression, so as to provide evidence for scientific training. DATA SOURCES： A computer-based online search of PubMed database was undertaken for the English articles about exercise and actin dated from June 1999 to June 2006 with the keywords of ＂actin, α-actin, α-actin mRNA, aerobic exercise＂. STUDY SELECTION： The data were firstly selected and the full-texts of articles about exercise and actin were looked over. Articles involved ①the study on the structure and function of actin, and ②expedmental studies on exercise and actin expression were included. Repetitive or similar researches, case report, and study tended to clinical medicine were excluded. DATA EXTRACTION： Totally 126 articles about exercise and actin were collected, and 31 were selected. DATA SYNTHESIS： Actin is one of the most conservative and abundant proteins in eukaryocytes. As the main component of cell framework and structure, actin has vital cell physiologic function. Globular actin and fibrous actin （microfilament） are the two forms of actin in body. As the main proteins constructing the myofilament of skeletal muscle, they participate all the contractive activities of muscle, and complete various mechanical movements in body. Protein is the expressive product of gene. The altemation of every link in gene expression would lead to the changes in protein content. Theoretically speaking, gene expression could be regulated at each stage during the expression; actually, it occurs at the initial stage of transcription. CONCLUSION： Various exercise pattems have different influences on the skeletal actin protein and mRNA expression.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第36期7236-7239,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
