摘要
目的探讨血管内皮生长因子(VEGF)与2型糖尿病肾病的关系。方法检测2型糖尿病患者122例和正常对照组40例血清VEGF水平,按尿微量白蛋白排泄率(UAER)水平分组比较检测结果。结果糖尿病各组患者血清VEGF水平较正常对照组显著升高,与糖化血红蛋白(HbA1C)、病程、UAER呈显著正相关(P<0.01)。结论血清VEGF与2型糖尿病肾病密切相关,其浓度的测定对判断2型糖尿病肾病的发生、发展有重要的临床意义。
Objective To explore the relationship between vascular endothelial growth factor （VEGF） and type 2 diabetic nephropathy. Methods Serum VEGF was measured in 40 control subjects and 122 patients with type 2 diabetic mellitus. The results were compared on the basis of urine albumin excretion rate levels. Results The serum VEGF concentration was sig- nificantly increased in all diabetic patients and it was positively correlated with glycosylated hemoglobin level, course of disease, and urine albumin excretion rate （ P 〈 0.01）. Conclusion VEGF is closely correlated with type 2 diabetic nephropathy. The detection of VEGF plays an important role in predicting the development and progression of type 2 diabetic nephropathy.
出处
《实用医院临床杂志》
2007年第5期30-31,共2页
Practical Journal of Clinical Medicine
基金
四川省医学科学院.四川省人民医院科研基金资助项目(303005002094016)
关键词
血管内皮生长因子
糖尿病肾病
2型糖尿病
Vascular endothelial growth factor
Diabetic nephropathy
Type 2 diabetes mellitus
