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冠心病患者血管内皮生长因子、超敏C反应蛋白水平变化及相关因素分析

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摘要 目的观察冠心病(CHD)患者血管内皮生长因子(VEGF)、超敏C反应蛋白(hs-CRP)水平的临床意义,并分析其与相关因素的关系。方法选取医院2013年1月-2014年1月住院治疗且被确诊为CHD患者101例为CHD组。另选取同期体检的健康成人100例为健康对照组。比较2组体质量指数(BMI)、腰臀比(WHR)、血糖、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血清VEGF、hs-CRP水平,应用Logistic回归分析VEGF、hs-CRP水平与相关因素的关系。结果与健康对照组相比,CHD组高血压、糖尿病、BMI、WHR、VEGF、hs-CRP水平差异均有统计学意义(P〈0.05)。相关因素分析,VEGF与BMI、WHR、DM呈正相关,hs-CRP与BMI、WHR呈正相关。Logistic回归分析,血清WHR(Or=6.435×1010,95%CI 1.949×104~2.125×1017,P=0.001)、hs-CRP(Or=8.164,95%CI 2.595~25.685,P=0.000)是CHD发病的独立危险因素。结论血清VEGF、hs-CRP水平以及WHR、BMI与冠心病密切相关;WHR、血清hs-CRP可作为冠心病的危险因素之一。
作者 张东霞
出处 《临床合理用药杂志》 2014年第29期79-80,共2页 Chinese Journal of Clinical Rational Drug Use
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