摘要
目的:观察清热养阴活血方剂逐瘀化消饮对DM大鼠肾脏VEGF表达的影响。方法:采用β-cyto-toxins大鼠模型,将Wistar大鼠随机分为正常组、模型组、胰岛素组、逐瘀化消饮低、中、高剂量+胰岛素组,观察糖尿病大鼠在胰岛素控制血糖基本一致的情况下,逐瘀化消饮治疗八周,用免疫组化方法检测DM大鼠肾脏组织中VEGF的分布状况。结果:与胰岛素组相比,逐瘀化消饮能抑制DM大鼠肾脏VEGF的表达。结论:逐瘀化消饮通过多种机制抑制DM大鼠肾脏VEGF表达,这可能是其防治DM大鼠肾脏微血管病变发生发展的机理之一。
Objective：To observe the effect on the expression of Vascular endothelial growth factor in kidney of diabetic rats by clearing heat,nourishing yin and activating blood.Methods：Imitated the model rats of diabetes mellitus（DM） induced by β-cytotoxins. Apart from the control groups,all the model rats were divided into five groups at random,namely the pathology group,Insulin group,the low dose ZYHXY and insulin group（ZYHXY-L）,the middle dose ZYHXY and insulin group（ZYHXY-M）,the high dose ZYHXY and insulin group（ZYHXY-H）. On the condition all the model rats had the same blood glucose controlled by insulin,observe the effect on the expression of VEGF in kidney after treated eight weeks by ZYHXY.Results：In comparing with the insulin groups,the low,middle,high dose groups of ZYHXY have the significant difference（P0.05）,in inhibiting the expression of VEGF in kidney.Conclusion：ZYHXY can inhibit the experession of VEGF in kidney,which is probably the one of the mechanism of treatment and prevention the diabetic angiopathy.
出处
《中华中医药学刊》
CAS
2010年第8期1693-1695,共3页
Chinese Archives of Traditional Chinese Medicine
基金
湖北中医学院科研课题(2004)
关键词
糖尿病
血管病变
实验研究
血管内皮生长因子
逐瘀化消饮
diabetes mellitus
laboratary study
vascular endothelial growth factor（VEGF）
Zhuyu Huaxiao Yin（ZYHXY）
