摘要
目的探讨检测TGF-β1、Smad4、VEGF的表达与大肠癌转移、复发的关系,分析其在大肠癌预后的意义。方法将病理确诊的大肠癌60例患者,按术后2～5年内有无临床复发、转移分为复发转移组30例和无瘤生存组30例,并进行TGF-β1、Smad4、VEGF免疫组化染色。结果TGF-β1及VEGF在复发转移组大肠癌组织中的表达水平明显高于无瘤生存组大肠癌组织,差异有显著性(P均<0.05)。Smad4在复发转移组大肠癌组织中的表达水平明显低于无瘤生存组(P<0.05)。结论TGF-β1在复发大肠癌组织中的表达上调,但其表达受Smad4的调控,而导致VEGF的表达上调可能参与大肠肿瘤复发与转移。
Objective To investigate the expressions of vascular endothelial growth factor （VEGF）, transforming growth factor- β1 （ TGF - β1 ） and Smad4, and to analyze the co expression of TGF - β1, VEGF, and Smad4 on predicting the prognosis of colorectal carcinoma. Method The expressions of VEGF,TGF-β1and Smad4 were determined with SP immunohistochemistry in 60 cases of colorectal carcinoma. Results The expressions of TGF - β1 and VEGF in recurrence colorectal carcinoma tissues were significantly higher than that in non- recurrence tissues（ P〈 0.05, P〈 0.05）. The expression of Smad4 in recurrence colorectal carcinoma tissues was significantly lower than that in non- recurrence tissues（P〈 0.05）. Conclusion The expression of TGF- β1 in recurrence colorectal carcinoma tissues is upregulated, and its expression is related with Smad4, while the up- regulated expression of VEGF might be concerned with the metastasis and recurrence of colorectal carcinoma.
出处
《实用预防医学》
CAS
2007年第4期1026-1028,共3页
Practical Preventive Medicine
