摘要
目的应用细胞遗传学方法对无精子症患者进行分析,探讨染色体核型异常与无精子症的关系以及对无精子症进行染色体分析的意义。方法对130例无精子症患者抽取外周血淋巴细胞培养,常规制片,G显带,进行染色体核型分析。结果发现异常核型48例,异常核型率为36.9%(48/130),其中有42例性染色体数目和结构的异常,约占异常核型的87.5%(42/48),4例常染色体结构异常,占异常核型的8.3%(4/48),另有2例为染色体变异,占异常核型的4.2%(2/48)。结论染色体异常是无精子症的重要原因,有必要对无精子症患者进行染色体检查,指导病因分析和治疗。
Objective ： To investigate the correlation of chromosomal abnormality with the azoospermia and to study the meaning of the karyotype analysis in azoospermis. Methods： Peripheral blood samples from 130 azoospermia patients were regular cultured, proeeeding, G - banding and analysed. Results ： 48 patients showed chromosomal abnormality and the incidence of chromosomal abnor- mality was 36. 9% （48/130）, of which 42 patients have abnormality in sex chromosome＇s number or structure, 4 patients have autosome abnormality, 2 patients have bias chromosomal variation. Conelution： Chromosomal abnormality is an important reason of azoospermia. It is necessary to take the chromosomal analysis for azoospermia patients, which can help analyze the reason of desease and supply important references for clinical therapy.
出处
《中国优生与遗传杂志》
2007年第8期107-108,共2页
Chinese Journal of Birth Health & Heredity
关键词
无精子症
染色体异常
核型分析
Azoospermia
Chromosomal abnormality
Karyotype analysis
