摘要
本文对30例95岁以上老人(长寿组)和30例中年人(对照组)细胞遗传学进行比较研究。结果表明,染色单体畸变率、姐妹染色单体互换(SCE)频率和亚二倍体细胞百分率长寿组均明显高于对照组(分别为2.3VS1.56/每100个细胞、5.3±1.5/细胞 VS 4.1±0.6/细胞和8.88％VS 6.78％,P<0.05),认为上述指标可作为衰老指标。而有丝分裂指数(6.85％VS 6.56％,P>0.05)两组无显著差异,说明长寿老人的细胞还能保持相当的分裂能力。加松胞素 B(CB)后双核细胞微核率两组差异不显著(15.2‰VS13.9‰,P>0.05),其意义尚需进一步研究。
Cytogenetics between 30 persons aged more than 95 years and 30 adults were compared.The rate of chromatid aberration(2.30 VS1.56%,P<0.05),sister chromatid exchange(SCE)frequencies(5.3±1.5 VS4.1±0.6 per cell,P<0.05),and hypodiploid(8.88 VS6.78%,P<0.05)were significautly different be- tween the longevous persons and the adults.The average mitosis index was found to be 6.85 VS 6.56%(P> 0.05).So it is believed that their increase may be an indication of aging,and that the cell in longevous persons can keep up the ability of exuberance.No significant difference were observed between these two groups in micronucleus frequencies obtained by cytochalasin B method(15.2 VS13.9%,P>0.05).
出处
《老年学杂志》
CSCD
1992年第6期359-361,共3页
