摘要
目的探讨同期放化疗方案在局部晚期鼻咽癌治疗中的价值。方法70例Ⅲ、Ⅳ期鼻咽癌患者随机分为单纯放疗组(对照组)和化疗+放疗组(研究组),每组35例,各有20例采用面颈联合野放疗。两组放疗方法、时间/剂量分割均相同。研究组按照北美Intergroup0099方案接受了同期放疗加辅助化疗。结果研究组和对照组的3年总生存率分别为70.0%和57.5%(P>0.05),无瘤生存率分别为59.2%和38.6%(P<0.05);3年局部控制率分别为81.6%和75.9%(P>0.05),无远处转移生存率为84.1%和66.1%(P<0.05)。结论放疗联合化疗可提高晚期鼻咽癌患者的无瘤生存率,降低远处转移率,并有改善总生存率的趋势。
Objective To evaluate the effect of concomitant chemo-radiotherapy for locally advanced nasopharyngeal carcinoma （NPC）. Methods Seventy patients with stage Ⅲ, Ⅳ NPC were randomly assigned to receive either simple radiotherapy （RT group, 35 cases） or chemo-radiotherapy （CT ＋ RT group, 35 cases）. In each group, 20 patients received radiotherapy with lateral facio-cervieal portals. Radiotherapy technique and dose were the same in both group. In CT ＋ RT group, patients were treated by intergroup 0099 regimen, consisting of CCRT using cisplatin 100 mg/m^2 on D1, 22 and 43 of radiotherapy, followed by ACT using cisplatin 80 mg/m2 every day and 5-Fu 1 g/m2 every 4days given from D 71, 99 and 127. Results Threeyear overall survival rate and 3-year disease-free survival rate were 70. 0% and 59. 2% in the CT＋ RT group, and 57. 5% and 38.6% in the RT group, respectively, showing a significant difference between the two groups in 3-year disease-free survival rate （P〈0. 05）. Three-year local control rate was 81.6% and 75. 9% in CT＋ RT group and RT group, respectively. There was significant difference in 3-year incidence of distant metastasis-free between the two groups （84. 1% vs 66. 1%）. Conclusion Concomitant chemo-radiotherapy can increase 3-year disease-free survival rate and reduce distant metastasis of the patients with locally advanced nasopharyngeal carcinoma. It also has a tendency to improve 3-year overall survival.
出处
《华中医学杂志》
2007年第4期292-293,295,共3页
Central China Medical Journal
关键词
鼻咽肿瘤
放射疗法
药物疗法
Nasopharyngeal carcinoma Radiotherapy Drug therapy
