摘要
目的:探讨端粒酶逆转录酶(human telomeras ereverse transcriptase,hTERT)mRNA的表达与贲门癌发生发展的关系。方法:用原位杂交技术检测80例贲门癌组织中hTERT mRNA的表达,并结合肿瘤的病理生物学行为进行分析。结果:80例贲门癌组织中hTERT mRNA阳性表达率为80%(64/80),明显高于正常贲门黏膜(0/20),χ2=44.44,P<0.01。hTERT mRNA阳性表达与贲门癌的分化程度呈显著性相关,χ2=4.56,P<0.05;但与贲门癌的TNM分期(χ2=0.211)、贲门癌的组织病理学类型(χ2=0.333)及有无淋巴结转移(χ2=0.318)无关,P值均>0.05。结论:hTERT mRNA阳性表达与贲门癌的发生及其生物学行为密切相关,可作为贲门癌早期诊断及评估预后的客观指标。
OBJECTIVE： To explore the correlation of hTERT mRNA expression with the occurrence and development of cardia cancer. METHODS：hTERT mRNA expression were studied by in situ hybridization in 80 samples of cardia cancer tissues. The study was also combined with the analysis of the pathological behavior. RESULTS： The positive rates of hTERT mRNA expression in cardia cancer and normal tissues were 80%（65/80） and （0/20）, respectively, which was significantly higher in the former than in the latter, x^2 =44.44, P% 0. 01. There was a significant diference in the positive rates of hTERT mRNA expression between the low and high diferentiated cardia cancer （x^2=4.56, P〈0. 05）, but the expression of hTERT mRNA was not related to the pathologic type （x^2= =0. 333）, TNM stage （x^2= =0. 211） and lymph node metastasis （x^2= =0. 318） of cardia cancer, P〉0. 05. CONCLUSION：The expression of hTERT mRNA is associated with the occurrence and pathological diagnosis and judging biologic behavior of cardia cancer.
出处
《中华肿瘤防治杂志》
CAS
2007年第18期1365-1367,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
胃肿瘤
贲门
原位杂交
端粒
末端转移酶
stomach neoplasms
cardia
in situ hybridizatiom telomerase
