摘要
目的探讨舍曲林联合眼动脱敏和再加工治疗对抑郁症的临床疗效及安全性。方法将64例抑郁症患者随机分为两组各32例,均给予舍曲林治疗,研究组联合眼动脱敏和再加工治疗,疗程均为6w。于治疗前及治疗第1w、2w、6w末采用汉密顿抑郁量表、临床总体印象量表评定临床疗效,副反应量表评定不良反应。结果治疗6w末研究组有效率87.5%,对照组为84.4%,两组差异无显著性(χ2=0.129,P>0.05)。汉密顿抑郁量表、临床总体印象量表评分,研究组治疗1w末均较对照组下降显著(P均<0.05),2w末均较对照组下降极显著(P均<0.01),6w末差异均无显著性(P均>0.05)。两组不良反应均轻微(P>0.05)。结论舍曲林联合眼动脱敏和再加工治疗治疗抑郁症疗效显著,起效更快,安全性高,依从性好。
Objective To explore the curative effects and safety of sertraline combined with the Eye Movement Desensitization and Reprocessing（EMDR） in treatment of depression. Methods 64 patients with depression were randomly divided into research group（n=32） receiving sertraline combined with the EMDR and control group（n=32） single sertraline for 6 weeks. Before treatment and at the ends of the lst,2nd and 6th week treatment, clinical curative effects were assessed with the Hamilton Depression Scale （HAMD） and Clinical Global Impression（CGI） and adverse reactions with the Treatment Emergent Symptom Scale（TESS）. Results At the end of the 6th week, effective rates were respectively 87.5% in the research and 84.4% in the control group, which showed no significant difference（P〉0.05）, the scores of HAMD and CGI decreased more significantly at the end of the 1st week（P〈0.05） and did very more significantly at the 2nd（P〈0.01） in the research than in the control group, therewas no significant difference at the end of the 6th（P〉0.05）. Adverse reactions of both the 2 groups were milder（P〉0.05）. Conclusion Sertraline combined with the EMDR takes effects faster and has higher safety and better compliance in the treatment of depression.
出处
《临床心身疾病杂志》
CAS
2007年第4期307-308,共2页
Journal of Clinical Psychosomatic Diseases
