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PPARs在梗阻性黄疸肝脏损伤中的作用 被引量:3

Roles of peroxisome proliferators-activated receptors in the liver damage by obstructive jaundice
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摘要 自从1990年过氧化体增殖剂激活受体(peroxisome proliferators—activated receptors,PPARs)被发现后,其各种生物学功能被陆续地阐明。研究表明,PPARs可能在基因转录水平对梗阻性黄疸肝脏损伤起到保护作用,这种保护作用的具体机制已经成为研究的热点。本文就此问题对近年来的研究进展做一综述。 Since its initial discovery in 1990, the diverse roles of the peroxisome proliferator-activated receptors (PPARs) have been elucidated. PPARs may act the protective effects against the obstructive jaundice-induced liver damage by regulating gene transcription. This protective mechanisms have becom the focus. This review will outline the advancement in this field.
作者 许海波 巩鹏
出处 《国际外科学杂志》 2007年第7期461-465,共5页 International Journal of Surgery
基金 国家自然科学基金项目(N0.30500110)
关键词 过氧化体增殖剂激活受体 梗阻性黄疸 肝损伤 peroxisome proliferators-activated recaptors PPARs obstructive jaundice liver damage
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