摘要
自从1990年过氧化体增殖剂激活受体(peroxisome proliferators—activated receptors,PPARs)被发现后,其各种生物学功能被陆续地阐明。研究表明,PPARs可能在基因转录水平对梗阻性黄疸肝脏损伤起到保护作用,这种保护作用的具体机制已经成为研究的热点。本文就此问题对近年来的研究进展做一综述。
Since its initial discovery in 1990, the diverse roles of the peroxisome proliferator-activated receptors (PPARs) have been elucidated. PPARs may act the protective effects against the obstructive jaundice-induced liver damage by regulating gene transcription. This protective mechanisms have becom the focus. This review will outline the advancement in this field.
出处
《国际外科学杂志》
2007年第7期461-465,共5页
International Journal of Surgery
基金
国家自然科学基金项目(N0.30500110)
关键词
过氧化体增殖剂激活受体
梗阻性黄疸
肝损伤
peroxisome proliferators-activated recaptors
PPARs
obstructive jaundice
liver damage