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PPAR-α与心血管疾病关系的基础研究进展 被引量:5

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摘要 越来越多的研究证实,动脉粥样硬化的病理学本质是血管壁对各种慢性损伤所作出的一种炎性反应。过氧化物酶体增殖激活受体(Peroxisome proliferators-activated receptor,PPAR-s)是一类由配体激活的核转录因子超家族成员,其分为PPAR-α、β(或δ)和γ三种亚型。近年来研究表明,PPAR-α对动脉粥样硬化的不同阶段均有作用,不仅能阻止动脉粥样硬化的发生与发展,还能稳定斑块,甚至能逆转动脉粥样斑块的发展,以防止急性心血管事件的发生。
出处 《海南医学》 CAS 2011年第3期28-30,共3页 Hainan Medical Journal
基金 海南省卫生厅科研课题项目(编号:琼卫200760)
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