摘要
过氧化物酶体增殖激活受体(PPAR s)是一类由配体激活的核转录因子,属核受体超家族成员之一。越来越多的研究认为PPAR s可通过调节全身脂质代谢,改善胰岛素抵抗,抑制巨噬泡沫细胞在血管壁的聚集及抑制炎症反应来发挥抗动脉粥样硬化的作用。现对其在动脉粥样硬化发生发展中的作用作一综述。
Peroxisome proliferator-activated receptors(PPARs) belong to the superfamily of nuclear receptors which are ligand-activated transcription factors.PPAR agonists are likely to exert their antiatherosclerotic properties by multiple mechanisms,including improving systemic lipid levels,improving insulin resistance,and inhibiting the accumulation of macrophage foam cells.
出处
《心血管病学进展》
CAS
2006年第z1期8-11,共4页
Advances in Cardiovascular Diseases
