摘要
研究了单酯法合成三氯蔗糖方法,采用蔗糖与原乙酸三乙酯的反应保护蔗糖6-位羟基,亚硫酰氯/吡啶选择性氯化制备三氯蔗糖。蔗糖6-乙酸酯的最佳氯化条件:蔗糖6-乙酸酯浆状物20g,吡啶22mL,亚硫酰氯20mL,反应介质1,2-二氯乙烷,回流时间10h。其氯化产物采用甲醇-甲醇钠水解脱去6-位羟基得到三氯蔗糖。
Having studied the method of synthesis of 4, 1′ ,6′ -trichloro-4, 1′ ,6′ -trideoxyalactosucrose by using monoesterification , we used the reaction of sucrose with triethyl orthoacetate to protect the 6-position hydroxyl group in sucrose. Sucralose was prepared by chlorinated sucrose 6-acetate with thionyl chloride/pyridine. The optimum chlorination condition： sucrose 6-acetate syrup （20 g）,Thionyl chloride （20 mL） pyrenyl （22 mL）,1,2-dichloroethane as reaction mediums and refluxed time was 10 hours. Thechlorinated product was hydrolyzed with methanol-sodium methoxide to deacetylation.
出处
《河北化工》
2007年第7期18-19,22,共3页
Hebei Chemical Industry
关键词
蔗糖
甜味剂
三氯蔗糖
单酯化
sucrose
sweetener
4, 1′ , 6′ -trichloro-4, 1′ , 6′ -trideoxygalactosucrose
monoesterification
