摘要
目的探讨乳腺黏液表皮样癌的临床病理特征。方法对1例罕见的乳腺黏液表皮样癌进行临床病理分析及免疫组化研究,并复习相关文献。结果患者女性,69岁。左乳腺包块巨检为灰红色类圆形肿块,与周围界限清楚;镜下肿瘤组织结节分叶状,以表皮样细胞为主,混杂有中间细胞和黏液细胞,可见较多大小不等的囊腔,腔内有黏液,细胞异型性不明显,偶见核分裂。免疫组化示AE1/AE3、34βE12和E-cadherin弥漫(+),S-100局灶(+)。结论乳腺黏液表皮样癌非常罕见,其组织形态学及生物学行为与涎腺黏液表皮样癌类似,确诊主要靠组织病理学,并辅以免疫组化标记,有时需要与腺鳞癌、腺样囊性癌或黏液癌鉴别。
Objective To study the clinicopathologic characteristics of mucoepidermiod carcinoma of the breast. Methods The clinicopathological and immunohistochemical findings in a case of mucoepidermiod carcinoma of the breast was presented with review of the relevant literature. Results The patient was female and 69 years old. The tumour was located in the right breast. Tumour was firm, multicystic, with well-defined edges. Histopathologically, epidermiod cell population was prominent with multcystic cavities filled with mucus. Immunohistochemical analysis showed that the tumour cells were diffusely positive for AE1/AE3, 34βE12, E-cadherin and focally positive for S-100. Conclusions Mucoepidermoid carcinoma is a very rare primary tumour of the breast. The morphology of this breast tumour is similar to its counterpart in the salivary gland. Definite diagnosis should be based mianly on pathological examination in assistance with immunohistochemical analysis. Differential diagnosis includes adenosquamous carcinoma, adenoid cystic carcinoma and mucinous carcinoma.
出处
《诊断病理学杂志》
CSCD
2007年第3期202-204,共3页
Chinese Journal of Diagnostic Pathology
关键词
乳腺
黏液表皮样癌
病理形态
免疫组化
Breast
Mucoepidermoid Carcinoma
Pathologic Morphology
Immunohistochemistry
