摘要
目的探讨乳腺嗜酸性细胞癌的病理组织特点、诊断及其鉴别诊断。方法通过光镜观察、免疫组化及组织化学染色观察1例女性乳腺嗜酸性细胞癌并复习有关文献。结果乳腺嗜酸性细胞癌组织学特点为癌细胞呈圆形或不规则形,胞浆宽广,内含大量嗜酸性颗粒,细胞核中度异形,核仁明显,核分裂象少见;癌细胞大多呈松散的大片块状分布,部分呈梁状、条索状或弥漫成巢状排列,伴有腺管及乳头形成。免疫组化染色癌细胞CK、EMA阳性表达,不表达SMA、S-100蛋白、CgA、Syn及GCDFP-15。PAS染色阴性。结论嗜酸性细胞癌是不同于大汗腺癌及嗜酸性神经内分泌癌的一种特殊类型乳腺癌。
Objective To inquire into the histopathologic characteristics of oncocytic carcinoma of the breast, its diagnosis and differential diagnosis. Methods A ease of primary oncocytic carcinoma of the female breast was studied by light microscopic observation and immunohistochemical stain, and literature review. Results The lesion was constituted by the proliferation of round to polygonal cells which had ＂low-grade＂ nuclei with a bundant cytoplasm full of deeply eosinophilie granules dispersing widely throughout it and prominent nucleoli. Immunohistochemical staining showed positive expression of CK and EMA in carcinoma cells, and no expression of SMA, S-100 protein, CgA, Syn, and GCDFP-15 in them. Conclusion Oncocytic carcinoma of the breast is a distinct variant which is different from apocrine carcinoma and eosinophilic neuroendocrine carcinoma.
出处
《基层医学论坛》
2006年第3期207-208,共2页
The Medical Forum
