摘要
脂肪因子包括脂肪细胞分泌的多种活性因子,它们通过内分泌方式调节胰岛β细胞的胰岛素分泌、基因表达以及细胞凋亡等多方面的功能。本文提出脂肪因子影响胰岛β细胞功能主要通过三条相互联系的途径而实现。第一是调节β细胞内葡萄糖和脂肪的代谢;第二是影响β细胞离子通道的活性;第三是改变β细胞本身的胰岛素敏感性。脂肪细胞的内分泌功能是一个动态过程,在不同的代谢状态下,各脂肪因子的分泌发生不同变化。从正常代谢状态发展到肥胖以及2 型糖尿病的过程中,脂肪因子参与了胰岛β细胞功能障碍的发生与发展。
Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic β-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence β-cell function through three inter- dependent pathways. The first is through regulating lipid and glucose metabolism in β-cells. The second implicates the change of ion channel opening and closing in β-cells. The third pathway is via the modification of insulin sensitivity of β-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of β-cell dysfunction in type 2 diabetes.
出处
《生理学报》
CAS
CSCD
北大核心
2007年第3期247-252,共6页
Acta Physiologica Sinica
基金
Australian NHMRC, Eli Lilly Australia
the National Natural Science Foundation of China
