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瘦素在免疫介导糖尿病自身免疫损伤中的作用 被引量:5

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摘要 研究表明瘦素水平可能在免疫介导糖尿病发病之前升高。瘦素可以促进致敏T淋巴细胞、单核细胞及自然杀伤细胞等免疫细胞的增殖、活化及向胰腺的迁移;促进细胞因子的分泌而加速β细胞凋亡,另外活化的T淋巴细胞也可以分泌瘦素,并可通过瘦素对胰岛β细胞造成损伤等。瘦素可能在胰岛细胞的自身免疫损伤中起了放大作用。
作者 陈涛 田浩明
出处 《国外医学(内分泌学分册)》 2005年第2期94-96,共3页 Foreign Medical Sciences(Section of Endocrinology)
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