摘要
血管内皮生长因子（VEGF）通过其特异性受体VEGF受体（VEGFR）发挥生物学功能。VEGFR包括VEGFR1-3和Neuropilins,VEGFR除分布于内皮细胞外,还表达于正常表皮、某些皮肤肿瘤和炎症性皮肤病中。VEGF-VEGFR信号传导通路可能在治疗这些皮肤疾病中成为重要的靶目标。
Vascular endothelial growth factor （VEGF） exerts its biological functions by its specific VEGF receptors （VEGFR） , which includes VEGFR-1, VEGFR-2, VEGFR-3, neuropilin-1, and neuropilin- 2. These VEGFR distributes in endothelial cells, and are also expressed in normal skin, inflammatory skin diseases, and skin cancers. The VEGF-VEGFR signaling pathway may be a new key target in the management of the skin diseases.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2007年第2期279-282,共4页
Acta Academiae Medicinae Sinicae
关键词
血管内皮生长因子
受体
银屑病
vascular endothelial growth factor
receptor
psoriasis
