摘要
目的探讨产后甲状腺炎(PPT)与人类白细胞抗原(HLA)-DP、HLA-DQ位点等位基因的相关性及产后甲状腺炎的遗传易患性。方法对2002年9月至2003年3月中国医科大学内分泌研究所研究队列中的52例PPT患者(临床PPT患者31例,亚临床PPT患者21例)和82名正常对照产妇采用聚合酶链反应-DNA序列分析(PCR-SBT)分型技术对HLA-DPA1、HLA-DPB1、HLA-DQA1、HLA-DQB1位点等位基因进行分型,比较各组间等位基因的基因表型频率分布差异。结果HLA-DPA1、HLA-DPB1、HLA-DQA1、HLA-DQB1位点等位基因的基因表型频率分布在各组间差异无显著性意义。结论产后甲状腺炎与HLA-DP、HLA-DQ位点可能无相关性。
Objective To study the genetic susceptibility in patients with postpartum thyroiditis （PPT）by genotyping their human leukocyte antigen （HLA）-DP and -DQ alleles. Methods The polymerase chain reaction-sequence based typing（PCR-SBP） method was used to analyze the distribution of HLA-DPA1, HLA-DPB1, HLA-DQA1 and HLA-DQB1 alleles among 52 PPT patients（31 clinical patients,21 subclinical patients）and 82 healthy controls. Compare the allele frequencies between various patient groups and the control population. Results There was no significant difference between patient group and control group. Conclusion Perhaps PPT is not associated with HLA-DP and HLA-DQ alleles.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2007年第10期751-754,共4页
Chinese Journal of Practical Internal Medicine
基金
国家自然科学基金(30370680)
