摘要
目的探讨产后甲状腺炎(PPT)与人类白细胞抗原-DQA1、-DQB1(HLA-DQA1、DQB1)位点等位基因的相关性及产后甲状腺炎的遗传易感性。方法采用多聚酶链反应-DNA序列分析(PCR-SBT)分型技术对52例PPT患者(临床PPT患者31例,亚临床PPT患者21例)和82例正常对照产妇进行HLA-DQA1、-DQB1位点等位基因的基因分型,比较各组间等位基因频率分布的差异。结果HLA-DQA1、DQB1位点等位基因频率分布在各组间差异无显著性。结论中国北方妇女产后甲状腺炎与HLA-DQA1、-DQB1位点可能无关联。
[Objective] To study the genetic susceptibility in patients with postpartum thyroiditis （PPT） by geno-typing their human leukocyte antigen DQA1 （HLA-DQA1） and -DQB1 alleles. [Methods] The polymerase chain reaction-sequence based typing （ PCR-SBT ） method was used to analyze the distribution of HLA-DQA1 and - DQB1 alleles among 52 PPT patients （31 chnical patients and 21 subcllnical patients） and 82 healthy controls. We compared the allele frequency between each group. [Results] There was no significent difference betweem patient group and control group. [Conclusion] Perhaps PPT was not associated with HLA-DQA1 and -DQB1 alleles in women in north China.
出处
《中国医学工程》
2007年第8期633-636,共4页
China Medical Engineering
基金
国家自然科学基金(30370680)
