摘要
质子泵抑制剂（PPI）是临床预防应激性溃疡中常用的抑酸药，通过作用于抑酸终末步骤而发挥强大的抑酸作用。与其他抑酸药相比，其不良反应较重，易导致原有病情恶化，给患者带来极大痛苦。近年来很多研究发现PPI的使用与肺炎发生密切相关，大致分为与社区获得性肺炎相关及与医院获得性肺炎相关两大类。本文对目前PPI与肺炎关联性的研究进展进行综述。
Proton pump inhibitors （PPI） are common acid-suppressing drugs in clinical preventive treatment of stress ulcer. PPI exerts strong acid-suppressing effect via acting on the terminal step of acid suppression. However, compared to other acid-suppressing drugs （H2 receptor antagonists, for instance）, PPI has more adverse reactions which leads to worse conditions. In recent years, many studies have found close relation between PPI and pneumonia（including community-acquired pneumonia and hospital-acquired pneumonia）. This article reviewed research progress of the relation between PPI and pneumonia.
出处
《中国医药》
2016年第11期1741-1744,共4页
China Medicine
