摘要
目的研究温州地区汉族人群妇女GNB3 C825T等位基因多态性与妊娠期间体重增加和产后超重及肥胖的相关性。方法在肥胖专科门诊、体检中心随机选取309例已产妇女,分为产后超重及肥胖组和产后体重正常对照组,PCR/RFLP检测基因型。结果(1)与对照组比较,产后超重及肥胖组的TT基因型携带率显著增加(P<0.01),TT/CT致产后肥胖的比数比(OR值)为2.6(95%可信区间1.4～4.6,P<0.01);TT/CC致产后肥胖的OR值为2.6(95%可信区间1.3～5.1,P<0.01);等位基因T与C比,致产后肥胖的OR值为1.5(95%可信区间1.1～2.1,P<0.01)。(2)妊娠期间体重增加值比较,TT型比CC型和CT型体重增加更显著(P<0.01),CT型比CC型体重增加亦明显(P<0.01);妊娠前后体重变化值比较,TT型比CC型和CT型产后体重明显增加(P<0.01),而CT型与CC型相比,其产后体重虽有增加,但差异无统计学意义(P=0.076)。结论GNB3 825T等位基因与妊娠期间体重较多增加和产后超重及肥胖密切相关。GNB3 825TT基因型可作为早期预测产后超重及肥胖的遗传学指标之一。
Objective To determine the relationship between C825T polymorphism in G protein beta 3 subunit （GNB3） gene and weight gain during pregnancy and postpartum obesity of HaM nationality population in Wenzhou. Methods This study included 309 female patients who were divided into postpartum obesity group and postpartum normal weight controls. Genotype was determined by PCR/RFLP. Results （1）TT genotype in postpartum obesity group increased significantly（P〈0.01 ）. Odds Ratio（OR）（TT/CT）for postpartum obesity was 2.6（95% CI 1.4-4.6, P〈0.01） OR （TT/CC）for postpartum obesity was 2.6（95% CI 1.3-5.1, P〈0.01）; OR（allele T/C）for postpartum obesity was 1.5（95% CI 1.1-2.1, P〈0.01） （2） The TT genotype carriers gained more weight than CC and CT genotype carriers（P〈0.001 ）,and CT carriers gained more weight than CC carriers（P〈0.01 ）; In addition, the weight gain of TT genotype carriers was significantly higher than that of CC and CT genotype carriers （P〈0.001）,the differences between weight gain of CT genotype carriers and that of CC carriers were not significant（P=0.076）. Conclusion GNB3 825T allele is positively associated with increased weight gain during pregnancy and postpartum obesity.GNB3 825T T genotype may be used as genetic marker in predicting the risk of developing postpartum obesity of Han nationality population.
出处
《浙江医学》
CAS
2007年第3期211-213,216,共4页
Zhejiang Medical Journal
