期刊文献+

免疫佐剂作用机制及CpG ODN作为新型佐剂的研究 被引量:4

The Reactive Mechanism of Immunoadjuvant and CpG ODN as a New Type of Immunoadjuvant
下载PDF
导出
摘要 免疫佐剂通过免疫调节作用等5种方式发挥功能,借助佐剂的非抗原特异性的多克隆激活是天然免疫细胞可能的作用机制.大部分佐剂通过直接参与天然免疫事件而间接/直接影响获得性免疫应答,不同的佐剂可针对不同的事件发挥作用.CpG ODN作为佐剂的优势在新近的研究中被逐渐发现. Immunoadjuvant functions through five major ways such as immune regulation,multi-activation by immnoadjuvant s irrantigen specialty may possibly the reactive mechanism in natural immune cells.Most adjuvant indirectly/directly affects acquired immune responses through directly participate in natural immune events,different adjuvant functions to vary events.CpG ODN s advantages as adjuvant is gradually discovered in recent researches.
出处 《生命科学研究》 CAS CSCD 2006年第S1期99-102,共4页 Life Science Research
关键词 佐剂 作用方式 模式识别理论 免疫应答 CPG ODN adjuvant function ways mode recognize theory immune response CpG ODN
  • 相关文献

参考文献2

二级参考文献42

  • 1Tokunaga T, Yamamoto H, Suganuma T, et al. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium boris BCG. I. Isolation, physicochemical characterization, and antitumor activity [J]. JNCI, 1984,72:955 - 962. 被引量:1
  • 2Yamamoto S, Yamamoto T, Tokunaga T, et 81. DNA from bacteria but not from vetebrates induces interferons, activates natural killer cells and inhibits tumor growth [J]. Microbiol Immunol, 1992, 36 (9) :983- 997. 被引量:1
  • 3Sato Y, Roman M, Tighe H, et al. Immunostimulatory DNA sequences necessary for effeetlve intradermal gene immunization. Science, 1996,273 : 352 - 354. 被引量:1
  • 4Daniela Verthelyi, Richard T. Kenney, Robert A. Seder, et al. CpG oligodeoxynucleotides as vaccine adjuvants in primates. The journal of immunology, 2002,1660- 1663. 被引量:1
  • 5Daniela Verthelyi, ken J. Ishii, et al. Human peripheral blood cells differentially recognize and respond to two disinct CpG motifs[J] .J Immunol, 2001,16 : 2372 - 2377. 被引量:1
  • 6Arthur M. Krieg, Tong Wu, et al. Sequence motifs in adenoviral DNA block immune activtion by stimulatory CpG motifs. Proc. Natl. Acad. sci. USA. Microbiology, 1998,95 : 12631 - 12636. 被引量:1
  • 7Himshi Yamada,Ihsan Gursel et al. Effect of suppressive DNA on CpG- induced immune activation[ J ]. Journal of immunology, 2002, 169:5590 - 5594. 被引量:1
  • 8HiroakiH. , Osamu. T. , et al. A toll - like receptor recognizes bacterial DNA. Naure,2000,408 : 740 - 745. 被引量:1
  • 9By Rose S., Oleg S. Targoni, Arthur M. Krieg, et al. CpG Oligodeoxynucleotides Acts as Adjuvants that Switch on T Helperl (Thl) Immunity. The Rockefeller University Press, November17, 1997,186(10): 1623 - 1631. 被引量:1
  • 10Susantha Gomis, Lorne Babiuk, Dale L. Godson, et al. Protection of chicken against Esoherichia coil infection by DNA containing CpG motifs. 2003,71 (2) :857- 863. 被引量:1

共引文献5

同被引文献83

引证文献4

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部