摘要
目的探讨利心I号对充血性心力衰竭(CHF)大鼠血流动力学、病死率及心肌细胞间黏附分子1(ICAM-1)表达的影响。方法利用阿霉素的心肌毒性复制CHF的动物模型。将84只Wistar雄性大鼠随机分为6组:对照组、单纯模型组、依那普利组、心宝丸组、利心I号低剂量组、利心I号高剂量组。各组均每日灌胃1次,连续灌胃4周,观察各组大鼠的一般状况及病死率,检测血流动力学变化,用免疫组化法测定ICAM-1基因蛋白的表达。结果利心I号能够改善CHF大鼠血流动力学参数,降低病死率,降低心肌细胞中ICAM-1的表达。结论利心I号通过降低CHF大鼠ICAM-1的表达,改善心功能。
AIM To investigate the beneficial effects of Linxin Ⅰ on the death rate hemodynamics changes and Intercellular adhesion molecule （ICAM-1） expression in rats with congestive heart failure （CHF）. METHODS Adriamycin was applied to establish CHF model and 84 male wistar rats were randomly divided into six groups： normal control group, model group, Enalapril control group, XinBao control group, high - dose Linxin Ⅰ group, and low - dose Linxin Ⅰ group. The general conditions and death rate of the rats were evaluated and hemodynamics changes were measured. ICAM-1 expression in the rat plasma was measured by immunohistochemical method. RESULTS Linxin Ⅰ improved the hemodynamie parameters, decreased the death rate and reduced ICAM-1 expression in the rat myocardial cells in CHF rats. CONCLUSION Linxin Ⅰ is effective in the treatment of CHF by decreasing the CHF rat tissue ICAM-1 expression.
出处
《心脏杂志》
CAS
2007年第2期166-169,共4页
Chinese Heart Journal
关键词
心力衰竭
充血性
利心Ⅰ号
心室重构
heart failure , congestive
Linxin Ⅰ
ventricular remodeling
