摘要
目的初步探讨限食对去卵巢肥胖大鼠体重的抑制效应及对血脂、血糖和激素水平的影响,为饮食治疗肥胖提供理论依据。方法将SD大鼠随机分为3组,即假手术组、单纯手术组、手术+限食组。单纯手术组和假手术组大鼠饮食不加限制,手术+限食组大鼠给予大鼠进食量的60%。每10天测量一次体重;手术后第56天测定血脂、血糖和激素水平的变化。结果大鼠行卵巢切除术后体重增加,血中雌激素和孕激素水平降低,胰岛素水平和血脂升高。限食的去卵巢肥胖大鼠体重明显减轻,血脂、血糖和胰岛素水平降低。结论限食可明显减轻去卵巢肥胖大鼠的体重,降低血脂,并可提高胰岛素的敏感性。
Objective To explore the effects of restricting food on body mass, serum lipid, glucose and hormone levels in ovariotomized obese rats and provide theoretic evidence for dietary therapy of obesity. Methods Healthy female SD rats were randomly divided into three groups, namely sham-operated group, ovariotomized group and ovariotomized ＋ restricting food group. Food intake was not confined in sham-operated group and ovariotomized group, and 60% of food diet was given to restricting food group. Body mass was measured every ten days in three groups. Rat＇s serum lipids, glucose and hormone levels were detected after 56 days of operation. Results Rats in ovariotomized group displayed increased body mass, decreased serum levels of estrogen and progesterone, enhanced levels of serum insulin and lipid. Rats in ovariotomized ＋restricting food group displayed decreased body mass, levels of serum lipid, glucose and insulin. Conclusion Restricting food could obviously reduce body mass, partly decrease serum lipid level, and increase insulin sensitivity.
出处
《兰州大学学报（医学版）》
CAS
2007年第1期9-11,共3页
Journal of Lanzhou University（Medical Sciences）
基金
国家自然科学基金(30572428)资助项目。
关键词
限食
去卵巢大鼠
体重
血脂
血糖
激素
restricting food
ovariotomized rats
body mass
serum lipid
serum glucose
hormone
