摘要
目的:观察补骨脂水煎剂对去卵巢肥胖大鼠体重、肿瘤坏死因子-α和瘦素的影响。方法:将SD雌性成年大鼠随机分为假手术组、手术组、补骨脂组,手术组、补骨脂组均行双侧卵巢切除术制备去卵巢肥胖模型,术后55 d经股动脉取血并测定雌激素、白细胞介素-6、肿瘤坏死因子-α和瘦素水平。结果:55 d后处死大鼠,手术组的体重、摄食量、肿瘤坏死因子-α水平和瘦素水平均高于假手术组(P<0.05),补骨脂组体重、摄食量、肿瘤坏死因子-α水平和瘦素水平均低于手术组(P<0.01),手术组和补骨脂组雌激素水平均低于假手术组(P<0.01)。结论:补骨脂水煎剂能够降低瘦素水平和肿瘤坏死因子-α水平,抑制摄食,降低去卵巢肥胖大鼠的体重。
Objective： To observe the effects of Fructus Psoraleae water decotion on weights,leptin and tumor necrosis fac- tor- alpha（ TNF- α） in ovariectomized obese rats. Methods： Adult female SD rats were randomly divided into sham operation, operation,and Fructus Psoraleae groups. Rats in operation and Fructus Psoraleae groups were underwent bilateral ovariectomy to prepare ovariectomized obese models. Femoral artery blood samples of the rats were collected to determine the levels of estrogen, interleukin- 6（ IL- 6）,leptin and TNF- α at the 55th days after operation. Results： The weight,food- intake,leptin and TNF- α levels of the rats in operation group were significantly higher than in sham operation group. The weight,food- intake, levels of leptin and TNF- α of rats in Fructus Psoraleae group were significantly lower than in operation group. The levels of es- trogen of rats in operation and Fructus Psoraleae groups were significantly lower than in sham operation group. Conclusion： Fruc- tus Psoraleae water decotion could decrease the levels of TNF- α and leptin,suppress food intake,and reduce the weight in ovariectomized obese rats.
出处
《包头医学院学报》
CAS
2013年第6期1-4,共4页
Journal of Baotou Medical College
基金
国家自然科学基金资助项目(30572428)
