摘要
目的研究邻苯二甲酸二丁酯(DBP)对果蝇生育力和寿命的毒性作用。方法将果蝇随机分为4组,分别给予含DBP为0,0.2%,0.6%和1.8%的培养基喂饲,雌雄配对产子,每日观察并记录子代孵化数和亲代存活数。结果各染毒组果蝇不育的比例高于对照组,1.8%浓度组果蝇的平均生育数显著低于对照组(P<0.05);随着DBP浓度的增加,雌蝇平均产卵期逐渐缩短;雌雄果蝇的平均寿命也逐渐缩短。结论DBP干扰了果蝇正常的生长发育和新陈代谢,使其生育能力降低,并加速其衰老。
Objective To study the effects of di - n - butyl phthalate（DBP） on the fecundity and the life span in drosophila melanogaster. Methods Drosophila melanogasters were divided randomly into four groups and were continuously fed with medium containing 0 %, 0.2 %, 0.6 %, 1.8 % DBP during entire trial period. The eclosion numbers of filial generation flies and the surviving numbers of parent flies were observed and recorded daily. Results The percent of sterility of drosophilas in DBP groups were higher than that in control group;the average reproduction of flies in 1.8 % DBP group was observably reduced as compared with control group（ P 〈 0.05 ）. The average proreation clays and the average life span of flies in DBP groups were gradually shortened with the rise of DBP concentration. Conclusion DBP can interfer flies＇ natural development and metabolism;reduce flies＇ fecundity;shorten flies＇ life span obviously in some degree.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2007年第3期303-304,共2页
Chinese Journal of Public Health
基金
上海市卫生局科研基金(054092)
关键词
邻苯二甲酸二丁酯
生育力
寿命
果蝇
di - n - butyl phthalate（DBP）
fecundity
life span
drosophila melanogaster
