期刊文献+

fascin蛋白在76例胃癌中的表达及其与临床、病理因素的关系 被引量:8

Expression of fascin in gastric carcinoma and its relationship with clinical and pathologic factor
下载PDF
导出
摘要 目的:探讨fascin蛋白在胃癌组织中的表达及其临床意义。方法:收集76例胃癌病例的临床病理资料,用免疫组织化学方法检测胃癌组织及自身对照正常胃壁组织中fascin蛋白表达。结果:正常胃壁组织无fascin表达,76例胃癌中有24例(31.6%)fascin表达阳性,而且其表达与胃癌WHO病理组织学分类、TNM分期、浆膜侵犯、淋巴结转移及远处转移相关,与年龄、性别无统计学相关性。结论:fascin蛋白在部分胃癌中呈阳性表达,并与胃癌局部侵袭和转移相关;它有助于胃癌患者的预后判断。 Objective:To investigate the clinical significance of fascin expression in gastric The clinic and pathological information of 76 cases of gastric carcinoma were collected.We detected the expression of fascin in the tissues of gastric carcinoma and compared with their own normal gastric tissues with immunohistochemical stain.Results:There was no expression of fascin in normal gastric tissues.Fascin protein was positive in 24 cases among the 76 gastric carcinoma and they correlated with pathological WHO classification,TNM staging,seresal invasion,lymphatic metastasis and distant metastasis.Fascin protein had no correlation with age and gender.Conclusion:The expression of fascin is positive in part cases of gastric carcinoma.It correlates with the local invasion and metastasis of gastric carcinoma.The expression of fascin can help to assess the prognosis of gastric carcinoma.
出处 《中日友好医院学报》 2007年第1期12-14,18,F0003,共5页 Journal of China-Japan Friendship Hospital
关键词 胃癌 FASCIN蛋白 免疫组织化学 转移 gastric carcinoma fascin immunochemistry metastasis
  • 相关文献

参考文献11

  • 1Ono S,Yamakita Y,Yamashiro S,et al.Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin[J].J Biol Chem,1997,272(4):2527-2533. 被引量:1
  • 2Adams JC,Clelland JD,Collett GD,et al.Cell-matrix adhesions differentially regulate fascin phosphorylation[J].Mol Biol Cell,1999,10:4177-4190. 被引量:1
  • 3Yamashiro S,Yamakita Y,Ono S,et al.Fascin,an actin-bunding protein,induces membrane protrusion and increases cell motility of epithelial cells[J].Mol Biol Cell,1998,9(5):993-1006. 被引量:1
  • 4Stanley RH,Lauri AA.虞积耀,崔全才主译.消化系统肿瘤病理学及遗传学[M].北京:人民卫生出版社,2006.46-50. 被引量:1
  • 5A Grothey,R Hashizume,AA Sahin and PD McCrea.Fascin,an actin-bundling protein associated with cell motility,is upregulated in hormone receptor negative breast cancer[J].British Journal of Cancer,2000,83(7):870-873. 被引量:1
  • 6Jawhari AU,Buda A,Jenkins M,et al.Fascin,an actin-bunding protein,modulates colonic epithelial cell invasiveness and differentiation in vitro[J].Am J Pathol,2003,162(1):69-80. 被引量:1
  • 7Tao YS,Edwards RA,Tubb B,et al.Beta-Catenin associates with the actin-bunding protein fascin in a noncadherin complex[J].J Cell Biol,1996,134(5):1271-1281. 被引量:1
  • 8Oving IM.Molecular causes of colon cancer[J].Eur Clin Invest,2002,32(6):448 -457. 被引量:1
  • 9Liotta LA,Mandler R,Murano G,et al.Tumor cell autocrine motility factor[J].Proc Natl Acid Sci USA,1986,48(10):3302-3306. 被引量:1
  • 10Hashimoto Y,Skacel M,Adamas JC.Role of fascin in human carcinoma motility and signaling:Prospects for a novel biomarker[J]? Int J Biochem Cell Biol,2005,37(9):1787-1804. 被引量:1

同被引文献107

引证文献8

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部