摘要
目的:探讨fascin蛋白在胃癌组织中的表达及其临床意义。方法:收集76例胃癌病例的临床病理资料,用免疫组织化学方法检测胃癌组织及自身对照正常胃壁组织中fascin蛋白表达。结果:正常胃壁组织无fascin表达,76例胃癌中有24例(31.6%)fascin表达阳性,而且其表达与胃癌WHO病理组织学分类、TNM分期、浆膜侵犯、淋巴结转移及远处转移相关,与年龄、性别无统计学相关性。结论:fascin蛋白在部分胃癌中呈阳性表达,并与胃癌局部侵袭和转移相关;它有助于胃癌患者的预后判断。
Objective:To investigate the clinical significance of fascin expression in gastric The clinic and pathological information of 76 cases of gastric carcinoma were collected.We detected the expression of fascin in the tissues of gastric carcinoma and compared with their own normal gastric tissues with immunohistochemical stain.Results:There was no expression of fascin in normal gastric tissues.Fascin protein was positive in 24 cases among the 76 gastric carcinoma and they correlated with pathological WHO classification,TNM staging,seresal invasion,lymphatic metastasis and distant metastasis.Fascin protein had no correlation with age and gender.Conclusion:The expression of fascin is positive in part cases of gastric carcinoma.It correlates with the local invasion and metastasis of gastric carcinoma.The expression of fascin can help to assess the prognosis of gastric carcinoma.
出处
《中日友好医院学报》
2007年第1期12-14,18,F0003,共5页
Journal of China-Japan Friendship Hospital