摘要
目的探讨滤泡树突细胞肉瘤的病理诊断及鉴别诊断。方法应用组织病理学及免疫组化观察6例(包括2例细针穿刺组织)滤泡树突细胞肉瘤的特点,并结合文献探讨其病理形态及鉴别诊断等。结果镜检肿瘤细胞为梭形、卵圆形,胞质丰富,可见小核仁,细胞呈片状、束状、编织状或漩涡状排列。免疫组化显示肿瘤细胞特异性地表达CD21、CD23、CD35、fascin、clusterin、D2-40、EMA,部分病例表达CXCL-13。结论滤泡树突细胞肉瘤是少见的低度恶性肿瘤,形态学上表现为梭形细胞呈漩涡状脑膜瘤样结构,CD21、CD35、EMA对于确诊有重要意义。Fascin、clusterin及CXCL-13可能成为滤泡树突细胞肉瘤的新标记物。
Purpose To explore pathologic diagnosis and differential diagnosis of follicular dendritic cell sarcoma （FDCS）.Methods Pathologic changes and immunohistochemical findings were observed with review of the literature,and differential diagnosis was discussed in six cases of follicular dendritic cell sarcoma,including 2 specimens of fine needle aspiration.Results Microscopically,the neoplastic cells were oval or spindle,with abundant cytoplasm and distinct small nucleoli.There were varied growth patterns in the tumor,such as fascicles,storiform,circularwhorls,and sheets.Tumor cells were positive for CD21,CD23,CD35,fascin,clusterin,D2-40 and EMA.Partial cases expressed CXCL-13.Conclusions Follicular dendritic cell sarcoma is a rare low grade malignant tumor.Microscopically,tumor cells are spindle-shaped in whorled patterns,and the diagnosis is based on the immunoprofile of CD21,CD35 and EMA.Fascin,CXCL-13 and clusterin might be new markers for follicular dendritic cells sarcoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2010年第5期565-568,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
滤泡树突细胞肉瘤
免疫组织化学
诊断
鉴别
follicular dendritic cell sarcoma
immunohistochemistry
diagnosis
differential
