摘要
目的了解儿童应用重组乙型肝炎（乙肝）疫苗（汉逊酵母）加强免疫的效果。方法采用血清流行病学调查方法，对新生儿按0、1、6个月程序完成重组乙肝疫苗（酵母）10μg、5μg、5μg3针接种，经筛查乙肝病毒表面抗原（HBsAg）、乙肝病毒表面抗体（抗-HBs）、乙肝病毒核心抗体（抗-HBc）均阴性的3～5岁儿童，加强接种重组乙肝疫苗（汉逊酵母）10μg，在免疫后5～6周采血，检测血清中抗-HBs。结果抗-HBs阳转率100％，抗体几何平均浓度809．00毫国际单位／毫升（mIU／m1）。结论儿童应用重组乙肝疫苗（汉逊酵母）加强免疫，能够刺激机体产生免疫反应，取得良好的加强免疫效果。
Objective To evaluate the efficacy of boostrer immunization of a recombinant Hansenule Polymorpha hepatitis B vaccine in infants. Methods To adopt serological epidemiology investigation on children who had achieved hepatitis B vaccine immunization three times following 0,1,6 months after birth, and the HBV（HBsAg, anti-HBs, anti-HBc）were negative, a reinforced immunization at 10μg of Hansenule Polymorpha hepatitis B Vaccine was effective. The anti-HBs inspection was conducted within 5 - 6 weeks after immunity. Result The positive conversion rate of anti-HBs was 100 %, and the geometric mean titers were 809.00 mIU/mL. Conclusion The booster immunization of a recombinant Hansenule Polymorpha hepatitis B vaccine among children has got better results.
出处
《中国计划免疫》
2007年第1期34-36,共3页
Chinese Journal of Vaccines and Immunization
关键词
重组乙型肝炎疫苗(汉逊酵母)
加强免疫
效果
Recombinant-yeast-derived hepatitis B vaccine （Hansenule Polymorpha）
Reinforce immunization
Efficacy
