摘要
[目的]评价成人按"0-1-3月""0-1-6月"和"0-1-12月"免疫程序接种乙型肝炎(乙肝)疫苗的免疫效果和持久性,为制定成人免疫策略提供依据。[方法]选择浙江省桐乡市16~49岁人群,按照自愿原则,分3种免疫程序接种10μg乙肝疫苗,全程免疫1个月和1年后定量检测抗-HBs,评价不同免疫程序接种后的抗-HBs阳转率、抗体浓度水平。[结果]共682人完成全程免疫并采集双份免疫后血样。全程免疫1个月后抗-HBs阳转率为99.85%,免疫1年后阳转率为70.23%,免疫年龄越低,抗-HBs阳转率和抗-HBs几何平均滴度越高。[结论]成年人接种10μg乙肝疫苗可获得较好的免疫效果,按"0-1-6月"免疫程序接种,目标人群依从性更好,免疫效果更持久。建议成年人尽早接种乙肝疫苗,以保证疫苗的免疫效果和持久性。
[ Objective ] To evaluate the immune effect of hepatitis B vaccine by axtterent inocula- ting programs for adults as 0 - 1 - 3 month, 0 - 1 - 6 month and 0 - 1 - 12 month and to provide evidence for the development of adult immunization strategy. [ Methods ] In Tongxiang City of Zhejiang Province, 10p^g of hepatitis B vaccine was voluntarily inoculated by different immunization programs as 0 - 1 - 3 month, 0 - 1 - 6 month or 0 - 1 - 12 month among adults aged 16 to 49 years. Quantitative detection of anti - HBs was conducted after 1 month and 1 year of immunization, and the positive seroconversion rates and geometric mean titers of anti - HBs （ GMT } were evaluated. [ Results ] Totally 682 subjects were evaluated. The anti - HBs positive rates were 99.85% after 1 month of immunization, and 70.23% after 1 year of immunization. It was observed that GMT of anti - HBs was higher with adults of younger age. [ Conclusion] Adults can achieve better immune effect by inoculation of 10μg of hepatitis B vaccine and when it is done in target population according to 0 - 1 - 6 month program, compliance is better and immune effect proves more early as possible to persistent. It is suggested that hepatitis B vaccine should be inoculated for the adults as ensure the effect and persistence of the vaccine
出处
《上海预防医学》
CAS
2015年第7期392-395,共4页
Shanghai Journal of Preventive Medicine
关键词
成人
乙肝疫苗
免疫程序
免疫效果
免疫持久性
Adult
Hepatitis B vaccine
Vaccination program
Immune effect
Immrme persistence
