摘要
目的:探讨了恶性葡萄胎患者化疗前后血清IL-2、SIL-2R和外周血B细胞及T淋巴细胞亚群水平及临床意义。方法:分别应用放射免疫分析、ELISA法和单克隆抗体法对32例恶性葡萄胎患者进行了血清IL-2、SIL-2R和外周血B细胞及T淋巴细胞亚群进行了检测,并与35名正常健康人作比较。结果:恶性葡萄胎患者在化疗前血清SIL-2R和B细胞数均非常显著地高于正常人(P<0.01),而IL-2、CD3、CD4、CD4/CD8比值则显著地低于正常人组(P<0.01),经化疗后6个月,与正常人比较仍有显著性差异(P<0.05)。结论:恶性葡萄胎患者是一种自身调节免疫异常的疾病。
Objective To study the clinical significance of changes of serum IL - 2, SIL - 2R level, peripheral blood B lymphocyte number and T - cell subsets after chemotherapy in patients with malignant hydatidiform mole. Methods Serum IL - 2 （ with RIA） SIL- 2R level （with ELISA） and peripheral blood B lymphocytes number as well as T subsets （with monoclonal antibody technique） were measured both before and after chemo therapy in 32 patients with malignant hydatidiform mole as well as in 35 controls. Results Before chemotherapy serum SIL-2R level and B lymphocyte were significantly higher in the patients than those in controls （P 〈0.01 ）, while the serum IL- 2 level CD3, CD4, CD4/CD8 were significantly lower （P 〈 0.01 ）. Six months after chemotherapy the levels changed markedly toward normal, but remained significantly different from those in controls （P 〈 0.05 ）. Conclusion Abnormal immuno -regulation were present in patients with malignant mole.
出处
《放射免疫学杂志》
CAS
2007年第1期36-38,共3页
Journal of Radioimmanology
