摘要
目的:观察热敏灸与药物对比治疗局限性白癜风的临床疗效差异,并探讨其作用机制。方法:将68例患者随机分为艾灸组(38例)和药物组(30例),另外随机抽取20名健康体检者作为正常组。艾灸组给予热敏灸,穴取合谷、曲池、阳陵泉、足三里、血海等,每日1次;药物组给予曲安奈德霜,局部外用,每日2次。两组均15天为一疗程,连续治疗3个疗程后观察疗效。所有观察者均进行血液流变学检测,应用放射免疫分析法检测白癜风患者治疗前后血清白介素-2(IL-2)、白介素-6(IL-6)、白介素-10(IL-10)和肿瘤坏死因子(TNF-α)水平。结果:白癜风患者在治疗前血清IL-6、IL-10、TNF-α水平显著地高于正常组(P<0.01,P<0.05),IL-2水平显著地低于正常组(P<0.01);经治疗3个疗程后,艾灸组可显著升高血清IL-2水平,降低IL-6、IL-10、TNF-α水平,与正常组比较差异无统计学意义(均P>0.05),但与药物组比较差异有统计学意义(P<0.05)。热敏灸治疗后愈显率为76.3%(29/38),显著高于药物组的13.3%(4/30,P<0.01)。结论:热敏灸治疗局限性白癜风具有很好的临床疗效,其机制可能与促进血液循环以及调节IL-2、IL-6、IL-10和TNF-α水平有关。
Objective To observe the difference in clinical efficacy on focal vitiligo treated with heat-sensitive moxibustion in comparison with medication, and discuss its effect mechanism. Methods Sixty-eight cases were randomized into a moxibustion group （38 cases） and a medication group （30 cases）. Additionally, 20 healthy per- sons were selected randomly as a normal group. In the moxibustion group, the heat-sensitive moxibustion was ap- plied to Hegu（LI 4）, Qucbi（LI 11）, Yanglingquan（GB 34）, Zusanli（ST 36）, Xuehai（SP 10） and the others, once a day. In the medication group, triamcinolone acetonide cream was used externally and locally, twice a day. In the two groups, the treatment of 15 days made one session. The efficacy was observed after continuous treatment for 3 sessions. The hemorheology test was done in all of the subjects. The radioimmunoassay was adopted to deter- mine the levels of Interleukin 2 （IL-2）, Interleukin 6 （IL-6）, Interteukin 10 （IL-10） and tumor necrosis factor （TNF-α） before and after treatment. Results The levels of IL-6, IL-10 and TNF-a in vitiligo patients were higher significantly than those in the normal group （P〈0.01,P〈0.05）, the level of IL-2 was lower significantly than that in the normal group （P〈0.01） before treatment, After 3 sessions treatment, IL-2 level was increased signifi- cantly in the moxibustion group and the levels of IL-6, IL-10 and TNF-α were reduced, without significant differ- ences as compared with the normal group （all P〈0.05）. But the differences were significant as compared with those in the medication group （all P〈0.05）. The curative and remarkably effective rate was 76.3% （29/38） after treatment in the moxibustion group, which was higher significantly than 13.3% （4/30, P〈0.05） in the medica- tion group. Conclusion Heat-sensitive moxibustion achieves very good clinical efficacy on focal vitiligo, which is probably via promoting blood circulation and regulating the levels of IL-6, IL-10 a
出处
《中国针灸》
CAS
CSCD
北大核心
2014年第4期337-340,共4页
Chinese Acupuncture & Moxibustion
