摘要
目的:探讨了银屑病患者外周血T-淋巴细胞亚群和血清IL-2、SIL-2R和TNF-α水平及意义。方法:分别应用放射免疫分析、酶法和单克隆抗体法对40例银屑病患者进行了外周血T-淋巴细胞亚群和血清IL-2、SIL-2R和TNF-α检测,并与35名正常健康人作比较。结果:银屑病患者血清IL-2、CD4/CD8比值明显低于正常人组(P<0.01),而SIL-2R和TNF-α水平则明显高于正常人组(P<0.01)。结论:检测银屑病患者血清IL-2、SIL-2R、TNF-α和外周血T-淋巴细胞亚群水平对其发病机理、了解病情、指导临床实践均具有重要的临床价值。
Obiective To investigate the changes of serum IL-2, SIL- 2R, TNF-α contents and T- cell subgroup distribution type in patients with psoriasis. Methods Serum IL- 2 and TNF -α levels were measured with RIA, SIL- 2R levels was measured with ELISA and T - cell subgroup distribution type was detected with monoclonal antibody in 40 patients with psoriasis and 35 controis. Results The serum IL- 2 levels and CD4/CD8 values were significantly lower in the patients than those in controls （P 〈 0. 01 ）, while the serum SIL - 2R, TNF - α levels were significantly higher （ P 〈 0.01 ）. Conclusion Determination of serum IL - 2, SIL- 2R, TNF- α contents and T- cell subgroup distribution type is clinically useful for understanding the disturbances of immunomodulation in these patients.
出处
《放射免疫学杂志》
CAS
2005年第6期445-447,共3页
Journal of Radioimmanology
